Progression of a Nelson’s adenoma to pituitary carcinoma; a case report and review of the literature

被引：0
作者：
S. A. G. Kemink
P. Wesseling
G. F. F. M. Pieters
A. A. J. Verhofstad
A. R. M. M. Hermus
A. G. H. Smals
机构：
[1] University Hospital Nijmegen,Dept of Endocrinology
[2] University Hospital Nijmegen,Dept of Neurology
[3] University Hospital Nijmegen,Dept of Pathology
来源：
Journal of Endocrinological Investigation | 1999年 / 22卷
关键词：
Metastasis; pituitary; carcinoma; Cushing; histology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 25-year-old woman developed Nelson’s syndrome, 3 years after successful bilateral adrenalectomy for Cushing’s disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, Ieading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing’s disease and Nelson’s syndrome and discuss the role of proliferation markers as indicators of malignant progression.
引用
收藏
页码：70 / 75
页数：5
相关论文
共 195 条
  • [1] Kemink L(1994)Patient’s age is a simple predictive factor for the development of Nelson’s syndrome after total adrena-lectomy for Cushing’s disease J. Clin. Endocrinol. Metab. 79 887-undefined
  • [2] Pieters G(1986)The occurrence of dural invasion in pituitary adenomas J. Neurosurg. 64 402-undefined
  • [3] Hermus A(1986)Pathology of invasive pituitary tumors with special reference to functional classification J. Neurosurg. 65 733-undefined
  • [4] Smals A(1996)The World Health Organization classification of ade-nohypophyseal neoplasms; a proposed five-tier scheme Cancer 78 502-undefined
  • [5] Kloppenborg T(1975)Dural invasion by pituitary tumours New Zealand Med. J. 81 386-undefined
  • [6] Selman W(1978)Conservative removal of small pituitary tumours: is it justified by the pathological findings? Neurol. Neurosurg. Psych. 41 283-undefined
  • [7] Laws E(1973)Transsphenoidal surgery of hypersecreting tumors Diagnosis and treatment of pituitary tumors 303 179-undefined
  • [8] Scheithauer B(1997)Pituitary Carcinoma; a clinicopathologic study of 15 cases Cancer 79 804-undefined
  • [9] Carpenter S(1996)Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody Neurosurg 35 1012-undefined
  • [10] Scheithauer B(1993)Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence J. Neurosurg. 78 753-undefined
12345678910