Basics of molecular diagnostics and therapy of malignant tumors

被引：1
|
作者：
Daniel P.T. [1 ,2 ,3 ,4 ]
Dörken B. [1 ,2 ,3 ]
机构：
[1] Medizinische Klinik Mit Schwerpunkt Hämatologie und Onkologie, Charité-Universitätsmedizin Berlin, Humboldt Universität, Berlin
[2] Medizinische Klinik Mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Charité-Universitätsmedizin Berlin, Humboldt Universität, Berlin
[3] Max Delbrück Centrum für Molukulare Medizin, Berlin
[4] Medizinische Klinik Mit Schwerpunkt Hämatologie und Onkologie, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, 13353 Berlin
来源：
Der Internist | 2005年 / 46卷 / 8期
关键词：
Malignant tumors; Molecular diagnostics; Molecular therapy; Oncogene; Pharmacogenetics; Targeted therapy;
D O I：
10.1007/s00108-005-1470-1
中图分类号：
学科分类号：
摘要：
Recent insights in disease pathogenesis and mechanisms of resistance to therapy of malignant tumors provide a rational basis for the development of novel therapeutic strategies that target genetic defects and deregulated signaling events in malignant tumors. In contrast to conventional therapeutics, small molecule inhibitors or monoclonal antibodies allow for a far more selective, targeted therapy of tumors that carry a corresponding target structure or gene expression profile. Molecular therapeutics therefore necessitate clinical deployment of genetic diagnostics for the identification of those patients who have a chance to benefit from these novel targeted therapies. © Springer Medizin Verlag 2005.
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收藏
页码：835 / 846
页数：11
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