Selective SERCA2a activator as a candidate for chronic heart failure therapy

被引:0
作者
Martina Arici
Shih-Che Hsu
Mara Ferrandi
Paolo Barassi
Carlotta Ronchi
Eleonora Torre
Andrea Luraghi
Gwo-Jyh Chang
Patrizia Ferrari
Giuseppe Bianchi
Francesco Peri
Antonio Zaza
Marcella Rocchetti
机构
[1] Università Degli Studi di Milano-Bicocca,Department of Biotechnology and Biosciences
[2] CVie Therapeutics Limited,undefined
[3] Windtree Therapeutics Inc,undefined
[4] Chang Gung University,undefined
[5] Università Vita-Salute San Raffaele,undefined
来源
Journal of Translational Medicine | / 22卷
关键词
SERCA2a; Istaroxime; PST3093; Heart failure; Diastolic dysfunction; STZ;
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[1]  
Chioncel O(2017)Clinical phenotypes and outcome of patients hospitalized for acute heart failure : the ESC heart failure long-term registry Eur J Heart Fail 19 1242-1254
[2]  
Mebazaa A(2022)Trends and complications associated with acute new—onset heart failure : a national readmissions database—based cohort study Heart Fail Rev 27 399-406
[3]  
Harjola V(2011)Cardiac gene therapy with SERCA2a: From bench to bedside J Mol Cell Cardiol 50 803-12
[4]  
Coats AJ(2002)Pharmacological profile of the novel inotropic agent (E, Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744) J Pharmacol Exp Ther 303 592-600
[5]  
Piepoli MF(2005)Modulation of sarcoplasmic reticulum function by Na+/K + pump inhibitors with different toxicity: digoxin and PST2744 [(E, Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride] J Pharmacol Exp Ther 313 207-215
[6]  
Crespo-leiro MG(2008)Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent. A randomized controlled trial in patients hospitalized with heart failure J Am Coll Cardiol 51 2276-85
[7]  
Mir T(2009)Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in P Am Heart J 157 1035-1041
[8]  
Uddin M(2007)Hemodynamic properties of a new-generation positive luso-inotropic agent for the acute treatment of advanced heart failure Am J Cardiol 99 41A-46A
[9]  
Qureshi WT(2023)Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac functions J Pharmacol Exp Ther 384 231-244
[10]  
Shanah L(2020)Treatment with 24 hour istaroxime infusion in patients hospitalised for acute heart failure: a randomised, placebo-controlled trial Eur J Heart Fail 22 1684-1693