Immunohistochemical Analysis of Vascular Endothelial Growth Factor and Hepatocyte Growth Factor, and Their Receptors, in Transplanted Islets in Rats

被引：0

作者：

Hiroaki Watanabe

Shoichiro Sumi

Yoshinori Kitamura

Yoshinori Nio

Tetsuya Higami

机构：

[1] University of Texas Medical Branch,Department of Surgery

[2] Kyoto University,Department of Organ Reconstruction, Institute for Frontier Medical Sciences

[3] Shimane Medical University,First Department of Surgery

来源：

Surgery Today | 2003年 / 33卷

关键词：

Islet transplantation; Vascular endothelial growth factor; Hepatocyte growth factor; Flk-1; c-Met;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. Our previous studies showed that transplanted islets increasingly express a marker of neovascularization, platelet endothelial cell adhesion molecule-1 (PECAM-1), as well as vascular endothelial growth factor (VEGF). Hepatocyte growth factor (HGF) is another stimulator of neovascularization. In this study, we examined the expression of these growth factors and their receptors; fetal liver kinase-1 (Flk-1) for VEGF and c-Met for HGF, to acertain whether VEGF and HGF play a role in the neovascularization of transplanted islets.

引用

页码：854 / 860

页数：6