Molecular mechanism of signaling by tumor necrosis factor

被引：0
作者：
Jikun Zha
Hongbing Shu
机构：
[1] Peking University,College of Life Sciences
[2] National Jewish Medical and Research Center,undefined
来源：
Science in China Series C: Life Sciences | 2002年 / 45卷
关键词：
tumor necrosis factor; signal transduction; JNK kinase; NF-κB; apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal transduction pathways triggered by TNF include those that lead to apoptosis, activation of transcription factor NF-κ B and protein kinase JNK. This review will discuss the molecular mechanisms of these signaling pathways.
引用
收藏
页码：113 / 119
页数：6
相关论文
共 136 条
  • [1] Carswell E. A.(1975)Endotoxin-induced serum factor that causes necrosis of tumors Proc. Natl. Acad. Sci. USA 72 3666-3670
  • [2] Old L. J.(1986)An overview of the history and biological properties of tumor necrosis factors Springe. Semin. Immun. 9 33-37
  • [3] Kassel R. L.(1995)How do tumor necrosis factor receptors work? J. Immfla. 45 221-238
  • [4] Shalaby M. R.(1995)Two tumor necrosis factor receptors: structure and function Trends in Cell Biology 5 392-399
  • [5] Pennica D.(1994)Anovel family of putative signal transducers associated with the cytoplasmic domain of the 75kDa tumor necrosis factor receptor Cell 78 681-692
  • [6] Palladino M. A.(1995)The TNFR2-TRAF signaling complex contains two novel proteins related to Baculovirus inhibitor of apoptosis proteins Cell 284 1243-1252
  • [7] Bazzoni F.(1998)NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress Caspase-8 activation Science 281 1680-1683
  • [8] Beutler B.(1995)TRAF2-mediated activation of NF-κB by TNF-receptor 2 and CD40 Science 269 1424-1426
  • [9] Vandenabeele P.(1997)Tumor necrosis factor α-induced activation of c-Jun N-terminal kinase is mediated by TRAF2 EMBO J. 16 1080-1092
  • [10] Declercq W.(1999)Prevention of constitutive TNF receptor 1 signaling by silencer of death domains Science 283 543-546
12345678910