Apoptosis of uninfected cells induced by HIV envelope glycoproteins

被引：69
作者：
Ahr B. [1 ]
Robert-Hebmann V. [1 ]
Devaux C. [1 ]
Biard-Piechaczyk M. [1 ]
机构：
[1] Lab. Infect. Retrov./Signal. Cell., CNRS UMR 5121-UMI, Institut de Biologie, 34960 Montpellier Cedex 2
来源：
Retrovirology | / 1卷 / 1期
关键词：
Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Simian Immunodeficiency Virus; Human Immunodeficiency Virus Patient; Human Immunodeficiency Virus Disease;
D O I：
10.1186/1742-4690-1-12
中图分类号：
学科分类号：
摘要：
Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection. Although multiple mechanisms contribute to the gradual T cell decline that occurs in HIV-infected patients, programmed cell death of uninfected bystander T lymphocytes, including CD4+ and CD8+ T cells, is an important event leading to immunodeficiency. The HIV envelope glycoproteins (Env) play a crucial role in transducing this apoptotic signal after binding to its receptors, the CD4 molecule and a coreceptor, essentially CCR5 and CXCR4. Depending on Env presentation, the receptor involved and the complexity of target cell contact, apoptosis induction is related to death receptor and/or mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated cell death leading to T cell depletion and clinical complications and covers the sometimes conflicting studies that address the possible mechanisms of T cell death. © 2004 Ahr et al; licensee BioMed Central Ltd.
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页数：12
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