Synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones catalyzed by heteropolyacids

被引：0
作者：
Zheng Dong Fang
Di Fang
Yu Yuan Tan
机构：
[1] Hubei Normal University,College of Chemistry and Environmental Engineering
[2] College of Art and Science of Hubei Normal University,undefined
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
Pyrimido[4,5-; ]pyrimidin-4(3; )-one; Heteropolyacids; Synthesis; Catalyst;
D O I：
暂无
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学科分类号：
摘要：
A series of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones have been synthesized in good yields by reaction of 4-amino-2-methylpyrimidine-5-carboxamide with aromatic aldehydes in the presence of three heteropolyacids, H3PMo12O40, H3PW12O40, and H5PV2Mo10O40. In this reaction the catalytic activity of H3PMo12O40 and H3PW12O40 was lower than that of H5PV2Mo10O40. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1H NMR, 13C NMR, and ESIMS). It is an effective way of synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-one derivatives, with the advantages of mild reaction conditions, simple operation, and good yields.
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页码：1203 / 1211
页数：8
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