Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart

被引：0
作者：
T. L. Zefirov
I. I. Khabibrakhmanov
N. I. Ziyatdinova
A. L. Zefirov
机构：
[1] Kazan (Volga Region) Federal University,Department of Human Health Protection
[2] Kazan Federal Medical University,Department of Normal Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 162卷
关键词：
heart; chronotropy; α; -adrenoceptor; methoxamine; rat;
D O I：
暂无
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学科分类号：
摘要：
The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
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页码：4 / 6
页数：2
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