ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis

被引：0
作者：
E. P. Demina
V. V. Miroshnikova
T. I. Rodygina
P. S. Kurianov
A. G. Vinogradov
A. D. Denisenko
A. L. Schwarzman
机构：
[1] Russian Academy of Sciences,St. Petersburg Nuclear Physics Institute
[2] Pavlov State Medical University,undefined
[3] St. Petersburg Institute of Experimental Medicine Russian Academy of Medical Sciences,undefined
来源：
Molecular Biology | 2011年 / 45卷
关键词：
atherosclerosis; reverse cholesterol transport; macrophage; ABCA1 transporter;
D O I：
暂无
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学科分类号：
摘要：
ABCA1 transporter is known to play an important role in cholesterol transport from peripheral tissues. However, its contribution to atherosclerosis development remains obscure. Using Real Time PCR, we detected a significant reduction of ABCA1 mRNA level in leukocytes of patients with atherosclerosis compared to control. Mean ABCA1 expression levels in leukocytes from the group of patients and from the control group were 0.57 ± 0.28 and 0.93 ± 0.14 (p = 0.02). At the same time, we revealed a significant increase of ABCA1 mRNA level in macrophages of patients compared to control. Mean ABCA1 expression levels in macrophages from the group of patients and from the control group were 1.32 ± 0.10 and 0.90 ± 0.14 (p = 0.014). In summary, we suggest that the expression level of ABCA1 gene may regulate atherosclerosis development.
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页码：258 / 262
页数：4
相关论文
共 216 条
[1]  
Fredenrich A.(2003)Reverse cholesterol transport, high density lipoproteins and HDL cholesterol: Recent data Diabetes Metab. 29 201-205
[2]  
Bayer P.(2006)Antiatherogenic role of high-density lipoproteins: Insights from genetically engineered mice Frontiers Biosci. 11 1328-1348
[3]  
Escola-Gil J.C.(2005)ATP-binding cassette transporter A1: A cell cholesterol exporter that protects against cardiovascular disease Physiol. Rev. 85 1343-1372
[4]  
Calpe-Berdiel L.(2006)ABCA1 and biogenesis of HDL J. Atheroscler. Thromb. 13 1-15
[5]  
Palomer X.(1999)Mutations in Nature Genet. 22 336-345
[6]  
Ribas V.(1999) in Tangier disease and familial high-density lipoprotein deficiency Nature Genet. 22 347-351
[7]  
Ordonez-Llanos J.(1999)The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease Nature Genet. 22 352-355
[8]  
Blanco-Vaca F.(1994)Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 Atherosclerosis. 107 85-98
[9]  
Oram J.F.(1980)Homozygous Tangier disease and cardiovascular disease Ann. Intern. Med. 93 261-266
[10]  
Heinecke J.W.(2008)Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease) J. Am. Med. Assoc. 299 2524-2532
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