Plasma neuregulin 1 as a synaptic biomarker in Alzheimer’s disease: a discovery cohort study

被引:0
作者
Agathe Vrillon
François Mouton-Liger
Matthieu Martinet
Emmanuel Cognat
Claire Hourregue
Julien Dumurgier
Elodie Bouaziz-Amar
Ann Brinkmalm
Kaj Blennow
Henrik Zetterberg
Jacques Hugon
Claire Paquet
机构
[1] Université Paris Cité,Clinical Neurochemistry Laboratory
[2] Inserm U1144,Department of Neurodegenerative Disease
[3] Université Paris Cité,undefined
[4] Center of Cognitive Neurology,undefined
[5] Lariboisière Fernand-Widal Hospital,undefined
[6] APHP,undefined
[7] Université Paris Cité,undefined
[8] Department of Biochemistry,undefined
[9] APHP GHU Nord Lariboisière-Fernand Widal,undefined
[10] Institute of Neuroscience and Physiology,undefined
[11] The Salhgrenska Academy at the University of Gothenburg,undefined
[12] Sahlgrenska University Hospital,undefined
[13] UK Dementia Research Institute at UCL,undefined
[14] UCL Institute of Neurology,undefined
[15] Hong Kong Center for Neurodegenerative Diseases,undefined
来源
Alzheimer's Research & Therapy | / 14卷
关键词
Alzheimer’s disease; NRG1; Synaptic pathology; Plasma biomarker;
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[1]  
Selkoe DJ(2002)Alzheimer’s disease is a synaptic failure Science 298 789-791
[2]  
Arendt T(2009)Synaptic degeneration in Alzheimer’s disease Acta Neuropathol 118 167-179
[3]  
DeKosky ST(1990)Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity Ann Neurol 27 457-464
[4]  
Scheff SW(1991)Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 30 572-580
[5]  
Terry RD(2020)In vivo imaging of synaptic loss in Alzheimer’s disease with [18F]UCB-H positron emission tomography Eur J Nucl Med Mol Imaging 47 390-402
[6]  
Masliah E(2018)Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging JAMA Neurol 75 1215-1224
[7]  
Salmon DP(2021)Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer’s disease Alzheimers Dement (Amst) 13 e12179-376
[8]  
Butters N(2018)Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology Acta Neuropathol 136 363-64
[9]  
DeTeresa R(2014)SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease Mol Neurodegener 9 53-e961
[10]  
Hill R(2019)Elevated CSF GAP-43 is Alzheimer’s disease specific and associated with tau and amyloid pathology Alzheimers Dement 15 55-1318