The role of human and mouse Y chromosome genes in male infertility

被引：0
作者：
Nabeel A. Affara
M. J. Mitchell
机构：
[1] University of Cambridge,Department of Pathology
[2] Faculté de Médecine,INSERM U.491, Génétique Médicale et Dévelopement
来源：
Journal of Endocrinological Investigation | 2000年 / 23卷
关键词：
Y chromosome; male fertility; deletions candidate genes;
D O I：
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学科分类号：
摘要：
It was suggested by Ronald Fisher in 1931 that genes involved in benefit to the male (including spermatogenesis genes) would accumulate on the Y chromosome. The analysis of mouse Y chromosome deletions and the discovery of microdeletions of the human Y chromosome associated with diverse defective spermatogenic phenotypes has revealed the presence of intervals containing one or more genes controlling male germ cell differentiation. These intervals have been mapped, cloned and examined in detail for functional genes. This review discusses the genes mapping to critical spermatogenesis intervals and the evidence indicating which are the most likely candidates underlying Y-linked male infertility.
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页码：630 / 645
页数：15
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