Physiological Modeling of Altered Pharmacokinetics of a Novel Anticancer Drug, UCN-01 (7-Hydroxystaurosporine), Caused by Slow Dissociation of UCN-01 from Human α1-Acid Glycoprotein

被引：0

作者：

Eiichi Fuse

Akitoshi Hashimoto

Natsuko Sato

Hiromi Tanii

Takashi Kuwabara

Satoshi Kobayashi

Yuichi Sugiyama

机构：

[1] Kyowa Hakko Kogyo Co.,Drug Development Research Laboratories, Pharmaceutical Research Institute

[2] Ltd.,Drug Development Research Laboratories, Pharmaceutical Research Institute

[3] Kyowa Hakko Kogyo Co.,Graduate School of Pharmaceutical Sciences

[4] Ltd.,undefined

[5] The University of Tokyo,undefined

来源：

Pharmaceutical Research | 2000年 / 17卷

关键词：

α1-acid glycoprotein; protein binding; dissociation rate; species difference; physiological model; pharmacokinetics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. The extremely low clearance and small distribution volumeof UCN-01 in humans could be partly due to the high degree of bindingto hAGP (1,2). The quantitative effects of hAGP on the pharmacokineticsof UCN-01 at several levels of hAGP and UCN-01 were estimatedin rats given an infusion of hAGP to mimic the clinical situation anda physiological model for analysis was developed.

引用

页码：553 / 564

页数：11

共 3 条

[1] Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human α1- acid glycoprotein
Fuse, E
Hashimoto, A
Sato, N
Tanii, H
Kuwabara, T
Kobayashi, S
Sugiyama, Y
PHARMACEUTICAL RESEARCH, 2000, 17 (05) : 553 - 564
[2] Reducing the impact of binding of UCN-01 to human α1-acid glycoprotein by encapsulation in liposomes
Yamauchi, M
Kusano, H
Nakakura, M
Kato, Y
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (07) : 1259 - 1264
[3] The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compound UCN-01
Landin, Erik J. B.
Williams, Christopher
Ryan, Sara A.
Bochel, Alice
Akter, Nahida
Redfield, Christina
Sessions, Richard B.
Dedi, Neesha
Taylor, Richard J.
Crump, Matthew P.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 297 (06)

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