Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents

被引：0
作者：
Young-Soo Kim
Ji-Young Lee
Junho Park
Wangtaek Hwang
Jongsung Lee
Deokhoon Park
机构：
[1] Biospectrum Life Science Institute,
[2] Biospectrum Life Science Institute,undefined
来源：
Archives of Pharmacal Research | 2010年 / 33卷
关键词：
Honokiol derivatives; Anti-bacterial;
D O I：
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学科分类号：
摘要：
Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.
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页码：61 / 65
页数：4
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