Infection models of human norovirus: challenges and recent progress

被引：0
作者：
Sangdo Ha
In-Soo Choi
Changsun Choi
Jinjong Myoung
机构：
[1] Chung-Ang University,School of Food Science and Technology
[2] Konkuk University,Department of Infectious Disease, College of Veterinary Medicine
[3] Chung-Ang University,Department of Food and Nutrition
[4] Chonbuk National University,Korea Zoonosis Research Institute
来源：
Archives of Virology | 2016年 / 161卷
关键词：
Virus Stock; Established Cell Line; Enteric Virus; Organoid Culture; Susceptible Cell Line;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Human norovirus (hNoV) infections cause acute gastroenteritis, accounting for millions of disease cases and more than 200,000 deaths annually. However, the lack of in vitro infection models and robust small-animal models has posed barriers to the development of virus-specific therapies and preventive vaccines. Promising recent progress in the development of a norovirus infection model is reviewed in this article, as well as attempts and efforts made since the discovery of hNoV more than 40 years ago. Because suitable experimental animal models for human norovirus are lacking, attractive alternatives are also discussed.
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页码：779 / 788
页数：9
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