The tubular epithelium in the initiation and course of intratubular nephrocalcinosis

被引：0
作者：
Benjamin A. Vervaet
Anja Verhulst
Marc E. De Broe
Patrick C. D’Haese
机构：
[1] University of Antwerp,Laboratory of Pathophysiology
来源：
Urological Research | 2010年 / 38卷
关键词：
Nephrocalcinosis; Tubular epithelium; Dedifferentiation; Crystal clearance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intratubular nephrocalcinosis is defined as the histological observation of calcium oxalate and/or calcium phosphate deposits retained within the lumen of the renal tubules. As the tubular epithelium is the primary interaction partner of crystals formed in the tubular fluid, the role of the epithelial cells in nephrocalcinosis has been investigated intensively. This review summarizes our current understanding on how the tubular epithelium mechanistically appears to be involved both in the initiation and in the course of nephrocalcinosis, with emphasis on in vivo observations.
引用
收藏
页码：249 / 256
页数：7
相关论文
共 407 条
[31]  
Lingeman JE(1966)The renal lesions of electrolyte imbalance. IV. The intranephronic calculosis of experimental magnesium depletion J Exp Med 2 263-278
[32]  
Coe FL(1968)On the forms of calcium oxalate deposits in the human kidney in oxalosis Beitr Pathol Anat 4 454-463
[33]  
Miller NL(1979)Histologic study of the early events in oxalate induced intranephronic calculosis Invest Urol 3 199-202
[34]  
Bledsoe SB(1979)Ultrastructural events in early calcium oxalate crystal formation in rats Kidney Int 6 640-650
[35]  
Sommer AJ(2004)Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria Urol Res 4 271-277
[36]  
Williams JC(2003)Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys J Am Soc Nephrol 12 3155-3166
[37]  
Shao Y(1998)Calcium oxalate crystal attachment to cultured kidney epithelial cell lines J Urol 4 1528-1532
[38]  
Worcester EM(2003)Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium J Am Soc Nephrol 1 107-115
[39]  
Kok DJ(1999)Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture Kidney Int 4 1426-1433
[40]  
Asplin JR(2000)Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells Kidney Int 3 1045-1054
12345678910