The tubular epithelium in the initiation and course of intratubular nephrocalcinosis

被引：0
作者：
Benjamin A. Vervaet
Anja Verhulst
Marc E. De Broe
Patrick C. D’Haese
机构：
[1] University of Antwerp,Laboratory of Pathophysiology
来源：
Urological Research | 2010年 / 38卷
关键词：
Nephrocalcinosis; Tubular epithelium; Dedifferentiation; Crystal clearance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intratubular nephrocalcinosis is defined as the histological observation of calcium oxalate and/or calcium phosphate deposits retained within the lumen of the renal tubules. As the tubular epithelium is the primary interaction partner of crystals formed in the tubular fluid, the role of the epithelial cells in nephrocalcinosis has been investigated intensively. This review summarizes our current understanding on how the tubular epithelium mechanistically appears to be involved both in the initiation and in the course of nephrocalcinosis, with emphasis on in vivo observations.
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页码：249 / 256
页数：7
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