Multifunctional Nanoparticulate Polyelectrolyte Complexes

被引：0
作者：
Sean M. Hartig
Rachel R. Greene
Mikhail M. Dikov
Ales Prokop
Jeffrey M. Davidson
机构：
[1] University of Texas MD Anderson Cancer Center,Divison of Pediatrics Research
[2] Vanderbilt University,Department of Chemical Engineering
[3] Vanderbilt University School of Medicine,Department of Medicine, Hematology/Oncology Division
[4] Vanderbilt University School of Medicine,Department of Pathology
[5] VA Tennessee Valley Healthcare System,Research Service
来源：
Pharmaceutical Research | 2007年 / 24卷
关键词：
biomaterials; controlled release/delivery; endothelial targeting; models; polyelectrolyte complexes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Water-soluble, biodegradable, polymeric, polyelectrolyte complex dispersions (PECs) have evolved because of the limitations, in terms of toxicity, of the currently available systems. These aqueous nanoparticulate architectures offer a significant advantage for products that may be used as drug delivery systems in humans. PECs are created by mixing oppositely charged polyions. Their hydrodynamic diameter, surface charge, and polydispersity are highly dependent on concentration, ionic strength, pH, and molecular parameters of the polymers that are used. In particular, the complexation between polyelectrolytes with significantly different molecular weights leads to the formation of water-insoluble aggregates. Several PEC characteristics are favorable for cellular uptake and colloidal stability, including hydrodynamic diameter less than 200 nm, surface charge of >30 mV or <−30 mV, spherical morphology, and polydispersity index (PDI) indicative of a homogeneous distribution. Maintenance of these properties is critical for a successful delivery vehicle. This review focuses on the development and potential applications of PECs as multi-functional, site-specific nanoparticulate drug/gene delivery and imaging devices.
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页码：2353 / 2369
页数：16
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