Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration

被引：0
作者：
M. N. Karpova
K. A. Zin’kovskii
L. V. Kuznetsova
N. V. Klishina
机构：
[1] Russian Academy of Medical Sciences,Research Institute of General Pathology and Pathophysiology
[2] Tver State Medical Academy,Department of Psychiatry, Narcology, and Medical Psychology with the Course of Psychiatry
[3] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2015年 / 158卷
关键词：
seizures; pentylenetetrazole; citicoline;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied the dose-dependent effect of preventive intraperitoneal injection of citicoline (cytidine 5′-diphosphocholine) on acute generalized epileptiform activity in C57Bl/6 mice. The duration of citicoline action was also evaluated. Administration of citicoline in doses of 500 and 1000 mg/kg 1 h before treatment with the convulsant agent pentylenetetrazole produced an anticonvulsant effect. This effect was manifested in an increase of the threshold of clonic seizures and tonic phase of seizures with lethal outcome. Moreover, the latency of seizure development was elevated under these conditions. The anticonvulsant effect of citicoline persisted for 6 h after its injection.
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页码：315 / 317
页数：2
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