Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation

被引：0

作者：

A Shimoni

M Körbling

R Champlin

J Molldrem

机构：

[1] The University of Texas MD Anderson Cancer Center,The Department of Blood and Marrow Transplantation

[2] Section of Transplant Immunology,Department of Blood and Marrow Transplantation

[3] University of Texas MD Anderson Cancer Center,undefined

来源：

Bone Marrow Transplantation | 2000年 / 26卷

关键词：

cryofibrinogenemia; lymphoma; stem cell transplantation; interleukin-2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up revealed the presence of cryofibrinogenemia and associated thrombotic vasculopathy. The patient was successfully treated with corticosteroids and therapeutic plasma exchange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may have occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2. Bone Marrow Transplantation (2000) 26, 1343–1345.

引用

页码：1343 / 1345

页数：2

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