A case–control study on the association of intestinal flora with ulcerative colitis

被引：0
作者：
Yin-hua Tang
Hong-cheng Liu
Guang Song
Tian-tian Wu
Ying Zhao
Li-jun Shi
机构：
[1] Harbin Medical University,Department of Gastroenterology, The First Affiliated Hospital
[2] Xiang’an Hospital of Xiamen University,Department of Digestive internal medicine
[3] Kaifeng Central Hospital,Department of Infectious Diseases
[4] Chifeng Clinical Medical School of Inner Mongolia Medical University,Department of Digestive internal medicine, Chifeng Municipal Hospital
来源：
AMB Express | / 11卷
关键词：
Ulcerative colitis; Intestinal flora; Species diversity; Species richness;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The association between intestinal flora and ulcerative colitis (UC) was studied in order to provide a basis and method for clinical treatment. Fresh fecal samples were collected from 30 active UC patients and 10 healthy controls. The intestinal flora DNA from each sample was extracted and 16S rRNA gene sequencing was carried out using HiSeq platform to identify the intestinal flora in fecal samples. The richness and diversity of intestinal flora in UC patients were significantly lower than those in healthy control group (P < 0.05). Significant differences were observed between the intestinal flora-species of UC patients and healthy controls. Synergistetes (P < 0.01) and Firmicutes (P < 0.05), along with probiotics Veillonella (P < 0.01), Ruminococcus and Coprococcus (P < 0.05) in the UC patients were lower than that in the healthy controls significantly. Furthermore, compared with the control group, Tenericutes (P < 0.01) and intestinal pathogenic bacteria, including Bacteroides (P < 0.01), Escherichia and Sutterella (P < 0.05) were significantly increased. The incidence of UC is significantly associated with the changes in intestinal flora. Changes in intestinal flora may lead to a decrease in the diversity of intestinal flora or to the enrichment of a particular intestinal flora.
引用
收藏
相关论文
共 229 条
[1]  
Ahlawat S(2021)Gut-organ axis: a microbial outreach and networking Lett Appl Microbiol 72 636-668
[2]  
Asha Y(2021)Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium Crit Rev Microbiol 47 254-273
[3]  
Sharma K(2018)Berberine regulates Treg/Th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon Front Pharmacol 9 571-494
[4]  
Ahlawat S(2019)A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages J Crohns Colitis 13 482-880
[5]  
Kumar P(2019)Long-term safety and efficacy of fecal microbiota transplant in active ulcerative colitis Drug Saf 42 869-56
[6]  
Mohan H(2018)From the intestinal flora to the microbiome Rev Esp Enferm Dig 110 51-450
[7]  
Goyal S(2013)Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Nature 504 446-346
[8]  
Sharma K(2008)Safety and clinical use of microecological preparations Adverse Drug React J 10 340-1210
[9]  
Cui H(2014)Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J Gastroenterol 20 1192-249
[10]  
Cai Y(2019)Emerging trends and research foci in gastrointestinal microbiome J Transl Med 17 67-1827
12345678910