Intraoperative radiation therapy of breast cancer: Evidence-based status

被引：0

作者：

Bottke D. ^{[1
]}

Scholz C. ^{[2
]}

Bottke R. ^{[1
]}

De Gregorio N. ^{[2
]}

Janni W. ^{[2
]}

Wiegel T. ^{[1
]}

机构：

[1] Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Ulm, 89081 Ulm

[2] Frauenklinik, Universitätsklinikum Ulm

来源：

Der Gynäkologe | 2013年 / 46卷 / 8期

关键词：

Breast-conserving therapy; Irradiation; Percutaneous; Postoperative; Randomized study;

D O I：

10.1007/s00129-013-3220-0

中图分类号：

学科分类号：

摘要：

The standard technique of postoperative radiotherapy after breast-conserving surgery is percutaneous irradiation of the entire breast which is usually followed by a tumor bed boost. Due to the increased detection of small breast carcinomas by mammographic screening, it is necessary to consider a possible change of the existing therapeutic practice. Since the majority of local recurrences occur close to the former tumor bed, the question arises whether a sole tumor bed irradiation might be a therapeutic alternative to total breast irradiation. At present prospective and randomized studies investigate for which patients an intraoperative radiotherapy is sufficient as the sole irradiation method after previous surgery. Intraoperative radiotherapy as a boost preceding percutaneous whole-breast irradiation is already possible according to a relevant statement of the DEGRO. © 2013 Springer-Verlag Berlin Heidelberg.

引用

页码：581 / 584

页数：3

共 17 条

[11] Janni W., Fleisch M.C., Huober J., Et al., Innovationen der gynäkologischen Onkologie, Gynäkologe, 45, pp. 669-677, (2012)
[12] Vaidya J.S., Joseph D.J., Tobias J.S., Et al., Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): An international, prospective, randomised, non-inferiority phase III trial, Lancet, 376, pp. 91-102, (2010)
[13] Vaidya Wenz J.S.F., Bulsara M., Et al., Targeted Intraoperative Radiotherapy for Early Breast Cancer: TARGIT-A Trial- Updated Analysis of Local Recurrence and First Analysis of Survival, (2012)
[14] Fyles A.W., McCready D.R., Manchul L.A., Et al., Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer, N Engl J Med, 351, pp. 963-970, (2004)
[15] Krauss D.J., Kestin L.L., Mitchell C., Et al., Changes in temporal patterns of local failure after breast-conserving therapy and their prognostic implications, Int J Radiat Oncol Biol Phys, 60, pp. 731-740, (2004)
[16] Veronesi U., Orecchia R., Luini A., Et al., Intraoperative radiotherapy during breast conserving surgery: A study on 1,822 cases treated with electrons, Breast Cancer Res Treat, 124, 1, pp. 141-151, (2010)
[17] Sautter-Bihl M.L., Sedlmayer F., Budach W., Et al., Intraoperative radiotherapy as accelerated partial breast irradiation for early breast cancer: Beware of one-stop shops?, Strahlenther Onkol, 186, pp. 651-657, (2010)

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