Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids

被引：0
作者：
E. Yu. Yamansarov
I. V. Saltykova
S. V. Kovalev
R. A. Petrov
D. O. Shkil’
E. I. Seleznev
E. K. Beloglazkina
A. G. Majouga
机构：
[1] M. V. Lomonosov Moscow State University,Department of Chemistry
[2] National University of Science and Technology MISIS,undefined
[3] D. Mendeleev University of Chemical Technology of Russia,undefined
来源：
Russian Chemical Bulletin | 2019年 / 68卷
关键词：
triterpenoids; alkynes; esterification; betulinic acid; oleanolic acid; ursolic acid; glycyrrhetic acid; cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structure—activity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
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页码：855 / 861
页数：6
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