Growth hormone and aging

被引：14
|
作者：
Bartke A. [1 ]
Brown-Borg H. [2 ]
Kinney B. [1 ]
Mattison J. [1 ,3 ]
Wright C. [1 ]
Hauck S. [1 ]
Coschigano K. [4 ]
Kopchick J. [4 ,5 ]
机构：
[1] Department of Physiology, Southern Illinois University, School of Medicine, Carbondale
[2] Department of Physiology, University of North Dakota, Edwin James Research Center, Grand Forks, ND 58202-9037
[3] Molecular Physiology and Genetics Section, National Institutes of Health, National Institute on Aging, Bethesda
[4] Edison Biotechnology Institute, Ohio University, Athens
[5] Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens
来源：
Journal of the American Aging Association | 2000年 / 23卷 / 4期
关键词：
Growth Hormone; Body Size; Body Composition; Life Span; Potential Usefulness;
D O I：
10.1007/s11357-000-0021-x
中图分类号：
学科分类号：
摘要：
The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse agerelated changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on growth, development, and adult body size may serve as important determinants of aging and life span, while the age-related decline in GH levels contributes to some of the symptoms of aging.
引用
收藏
页码：219 / 225
页数：6
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