Growth hormone and aging

被引：14

作者：

Bartke A. ^{[1
]}

Brown-Borg H. ^{[2
]}

Kinney B. ^{[1
]}

Mattison J. ^{[1
,3
]}

Wright C. ^{[1
]}

Hauck S. ^{[1
]}

Coschigano K. ^{[4
]}

Kopchick J. ^{[4
,5
]}

机构：

[1] Department of Physiology, Southern Illinois University, School of Medicine, Carbondale

[2] Department of Physiology, University of North Dakota, Edwin James Research Center, Grand Forks, ND 58202-9037

[3] Molecular Physiology and Genetics Section, National Institutes of Health, National Institute on Aging, Bethesda

[4] Edison Biotechnology Institute, Ohio University, Athens

[5] Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens

来源：

Journal of the American Aging Association | 2000年 / 23卷 / 4期

关键词：

Growth Hormone; Body Size; Body Composition; Life Span; Potential Usefulness;

D O I：

10.1007/s11357-000-0021-x

中图分类号：

学科分类号：

摘要：

The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse agerelated changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on growth, development, and adult body size may serve as important determinants of aging and life span, while the age-related decline in GH levels contributes to some of the symptoms of aging.

引用

页码：219 / 225

页数：6

共 50 条

[31] Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency
Pawlikowska-Haddal, Anna
EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (06) : 927 - 932
[32] Aging under endocrine hormone regulation
Xing, Yutong
Xuan, Fan
Wang, Kaixi
Zhang, Huifeng
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[33] Growth hormone treatment in adults with growth hormone deficiency: The transition
Molitch, M. E.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2011, 34 (02) : 150 - 154
[34] Benefits and risks of growth hormone in adults with growth hormone deficiency
Diez, Juan J.
Cordido, Fernando
MEDICINA CLINICA, 2014, 143 (08): : 354 - 359
[35] Growth hormone and adipose tissue: Beyond the adipocyte
Berryman, Darlene E.
List, Edward O.
Sackmann-Sala, Lucila
Lubbers, Ellen
Munn, Rachel
Kopchick, John J.
GROWTH HORMONE & IGF RESEARCH, 2011, 21 (03) : 113 - 123
[36] Growth hormone, insulin-like growth factor-1 and the aging brain
Ashpole, Nicole M.
Sanders, Jessica E.
Hodges, Erik L.
Yan, Han
Sonntag, William E.
EXPERIMENTAL GERONTOLOGY, 2015, 68 : 76 - 81
[37] Growth hormone -: Hormone replacement for the somatopause?
Savine, R
Sönksen, P
HORMONE RESEARCH, 2000, 53 : 37 - 41
[38] Regulation of ovarian function by growth hormone: Potential intervention of ovarian aging
Han, Lei
Tian, Hongcheng
Guo, Xiaoxiao
Zhang, Lei
FRONTIERS IN ENDOCRINOLOGY, 2023, 13
[39] ASPECTS OF THE NEUROENDOCRINE CONTROL OF GROWTH-HORMONE SECRETION IN AGING MAMMALS
MULLER, EE
CELLA, SG
COLONNA, VD
PARENTI, M
COCCHI, D
LOCATELLI, V
JOURNAL OF REPRODUCTION AND FERTILITY, 1993, : 99 - 114
[40] Aspects of the central nervous drive to growth hormone secretion during aging
E. E. Müller
S. G. Cella
A. E. Rigamonti
E. C. degli Uberti
M. R. Ambrosio
D. Cocchi
Aging Clinical and Experimental Research, 1997, 9 (Suppl 4) : 7 - 8

← 1 2 3 4 5 →