Linezolid-induced thrombocytopenia in impaired renal function: is it time for a dose adjustment? A case report and review of literature

[1] Parker RI(2012)Etiology and significance of thrombocytopenia in critically ill patients Crit Care Clin 28 399-411

[2] Loo AS(2012)Antimicrobial drug induced thrombocytopenia: a review of the literature Semin Thromb Hemost 38 818-829

[3] Gerzenhtein L(2004)Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6 J Antimicrob Chemother 54 832-835

[4] Ison MG(2006)No effect of pyridoxine on the incidence of myelosuppression during prolonged linezolid treatment Clin Infect Dis 43 89-91

[5] Spellberg B(2003)Mechanisms for linezolid-induced anemia and thrombocytopenia Ann Pharmacother 37 517-520

[6] Yoo T(2001)Linezolid and reversibile myelosuppression JAMA 285 1291-735

[7] Bayer AS(2012)A comparative evaluation of adverse platelet outcomes among Veterans’ Affairs patients receiving linezolid or vancomycin J Antimicrob Chemother 67 727-1064

[8] Plachouras D(2004)Similar hematologic effects of long-term linezolid and vancomycin therapy in a prospective observational study of patients with orthopedic infections Clin Infect Dis 38 1058-1616

[9] Giannitsioti E(2003)Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use Clin Infect Dis 37 1609-1808

[10] Athanassia S(2010)Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis Crit Care Med 38 1802-1142

[1] Parker RI(2012)Etiology and significance of thrombocytopenia in critically ill patients Crit Care Clin 28 399-411

[2] Loo AS(2012)Antimicrobial drug induced thrombocytopenia: a review of the literature Semin Thromb Hemost 38 818-829

[3] Gerzenhtein L(2004)Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6 J Antimicrob Chemother 54 832-835

[4] Ison MG(2006)No effect of pyridoxine on the incidence of myelosuppression during prolonged linezolid treatment Clin Infect Dis 43 89-91

[5] Spellberg B(2003)Mechanisms for linezolid-induced anemia and thrombocytopenia Ann Pharmacother 37 517-520

[6] Yoo T(2001)Linezolid and reversibile myelosuppression JAMA 285 1291-735

[7] Bayer AS(2012)A comparative evaluation of adverse platelet outcomes among Veterans’ Affairs patients receiving linezolid or vancomycin J Antimicrob Chemother 67 727-1064

[8] Plachouras D(2004)Similar hematologic effects of long-term linezolid and vancomycin therapy in a prospective observational study of patients with orthopedic infections Clin Infect Dis 38 1058-1616

[9] Giannitsioti E(2003)Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use Clin Infect Dis 37 1609-1808

[10] Athanassia S(2010)Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis Crit Care Med 38 1802-1142