The effect of prenatal cocaine exposure on the stress response of adult mice

被引:0
作者
Cleopatra S. Planeta
Jennifer Berliner
Andrew Russ
Barry E. Kosofsky
机构
[1] Universidade Estadual Paulista,Faculdade de Ciencias Farmaceuticas de Araraquara
[2] Albert Einstein School of Medicine,Associate Professor of Neurology
[3] Harvard Medical School,Laboratory of Molecular and Developmental Neuroscience
[4] Massachusetts General Hospital — East,undefined
来源
Neurotoxicity Research | 2001年 / 3卷
关键词
Brain Development; Corticosterone; Drugs of Abuse; Footshock-induced Freezing; HPA (Hypothalamic/Pituitary/Adrenal) Axis; Malnutrition; Prenatal Cocaine; Restraint Stress;
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学科分类号
摘要
The neurotoxic consequences of intrauterine exposure to drugs of abuse, including cocaine, may include compromised fetal brain development with associated lasting behavioral alterations. Some infants exposed to cocainein utero demonstrate impairments in reactivity and altered behavioral responses to stressful conditions. Alterations in arousal regulation can impact on socialization, adaptation, and educability. Moreover, such alterations may render cocaine-exposed children more vulnerable to the adverse developmental impact of stressful situations, with implications for subsequent behavior and psychopathology.
引用
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页码:53 / 64
页数:11
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