Pathways defective in the human premature aging disease Werner syndrome

被引：0
|
作者：
Vilhelm A. Bohr
Robert M. Brosh
Cayetano von Kobbe
Patricia Opresko
Parimal Karmakar
机构：
[1] National Institute on Aging,Laboratory of Molecular Gerontology
来源：
Biogerontology | 2002年 / 3卷
关键词：
aging; DNA metabolism; DNA repair; Werner syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.
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页码：89 / 94
页数：5
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