Arterial compliance and endothelial function

被引：38
作者：
Correia M.L.G. [1 ]
Haynes W.G. [1 ]
机构：
[1] General Clinical Research Center, University of Iowa, Iowa City, IA 52242
来源：
Current Diabetes Reports | 2007年 / 7卷 / 4期
基金：
美国国家卫生研究院;
关键词：
Arterial Stiffness; Nebivolol; Beraprost Sodium; Ection Wave;
D O I：
10.1007/s11892-007-0043-1
中图分类号：
学科分类号：
摘要：
Decreased arterial compliance (increased stiffness) correlates with cardiovascular events, possibly due to increased cardiac afterload caused by more rapidly reflected pulse waves. Endothelium-derived mediators regulate vascular tone and structure, both of which can markedly influence arterial stiffness. Thus, increased arterial stiffness may be a mechanism by which endothelial dysfunction predisposes to complications of atherosclerosis. Conversely, therapeutic manipulation of endothelial mediators could reduce arterial stiffness and cardiovascular events. Techniques have been developed that use measures of arterial stiffness as an index of endothelial dilator function; these may provide unique prognostic information to identify high-risk subjects. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：269 / 275
页数：6
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