The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review

被引：0
作者：
Sepideh Mahmoudzadeh
Hojjatollah Nozad Charoudeh
Cláudia Silva Marques
Saeed Bahadory
Ehsan Ahmadpour
机构：
[1] Tabriz University of Medical Sciences,Immunology Research Center
[2] Tabriz University of Medical Sciences,Student Research Committee
[3] Tabriz University of Medical Sciences,Stem Cell Research Center, Department of Applied Cell Sciences
[4] University of Porto,Center for Study in Animal Science, Institute for Agricultural and Agro
[5] National Institute of Health Dr. Ricardo Jorge,Alimentary Science and Technology (ICETA)
[6] Tabriz University of Medical Sciences,Department of Infectious Diseases, Laboratory of Parasitology
[7] Tabriz University of Medical Sciences,Infectious and Tropical Diseases Research Center
来源：
Parasitology Research | 2021年 / 120卷
关键词：
Cytokines; Interleukin 12; Interferon gamma; NK cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Toxoplasma gondii is an intracellular protozoan parasite that can remarkably infect, survive, and replicate in almost all mammalian cells and can cause severe neurological and ocular damage in immunocompromised individuals. It is known that Natural Killer cells (NK cells), as a type of cytotoxic lymphocyte, have critical protective roles in innate immunity during the T. gondii infection through releasing interferon gamma (IFN-γ). Interleukin 12 (IL-12) is a pivotal critical cytokine for the generation of IFN-γ–producing NK cells. Several studies have shown cytokines’ impact on NK cell activation; and IL-2 has an important role with a potent stimulatory factor for NK cells. In this review, we summarized the mechanism of interleukin-12 production stimulation by T. gondii tachyzoites and discussed several factors affecting this mechanism.
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页码：2303 / 2309
页数：6
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  • [1] Aldebert D(2007)Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line Cytokine 37 206-211
  • [2] Durand F(2020)Targeting strategies in therapeutic applications of toxoplasmosis: recent advances in liposomal vaccine delivery systems Curr Drug Targets 21 541-558
  • [3] Mercier C(2005)The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage Genome Biol 6 R92-R92
  • [4] Brenier-Pinchart M-P(2012)Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii Infect Immun 80 4298-4308
  • [5] Cesbron-Delauw M-F(1999)Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens J Immunol 162 7369-7375
  • [6] Pelloux H(1997)Cellular responses to interferon-gamma Annu Rev Immunol 15 749-795
  • [7] Azadi Y(2000)Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii Infect Immun 68 6932-6938
  • [8] Ahmadpour E(2007)Pulling together: an integrated model of Toxoplasma cell invasion Curr Opin Microbiol 10 83-89
  • [9] Ahmadi A(2017)Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more Semin Immunol 31 55-63
  • [10] Bekpen C(2014)Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis Infect Immun 82 4056-4067
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