Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

被引：0

作者：

Alice Giustacchini

Supat Thongjuea

Nikolaos Barkas

Petter S Woll

Benjamin J Povinelli

Christopher A G Booth

Paul Sopp

Ruggiero Norfo

Alba Rodriguez-Meira

Neil Ashley

Lauren Jamieson

Paresh Vyas

Kristina Anderson

Åsa Segerstolpe

Hong Qian

Ulla Olsson-Strömberg

Satu Mustjoki

Rickard Sandberg

Sten Eirik W Jacobsen

Adam J Mead

机构：

[1] MRC Molecular Hematology Unit,Department of Cellular Therapy

[2] Weatherall Institute of Molecular Medicine,Department of Cell and Molecular Biology

[3] University of Oxford,Department of Medicine

[4] Haemopoietic Stem Cell Biology Laboratory,Department of Medical Science and Division of Hematology

[5] Weatherall Institute of Molecular Medicine,Department of Clinical Chemistry and Hematology

[6] University of Oxford,undefined

[7] Norwegian Radium Hospital,undefined

[8] Oslo University Hospital,undefined

[9] Karolinska Institutet,undefined

[10] Integrated Cardio Metabolic Center (ICMC),undefined

[11] Karolinska Institutet,undefined

[12] Center for Hematology and Regenerative Medicine,undefined

[13] Karolinska Institutet,undefined

[14] University Hospital,undefined

[15] Hematology Research Unit Helsinki,undefined

[16] University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center,undefined

[17] Ludwig Institute for Cancer Research,undefined

[18] Karolinska University Hospital,undefined

[19] NIHR Biomedical Research Centre,undefined

[20] Churchill Hospital,undefined

来源：

Nature Medicine | 2017年 / 23卷

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摘要：

Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia reveals insight into the heterogeneity of cells that resist treatment with targeted therapy, as well as into the dynamics of disease progression and its effects on nontransformed hematopoietic stem cells.

引用

页码：692 / 702

页数：10

共 95 条

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