γ-Aminobutyric acid levels in the intercellular space in the nucleus accumbens of the rat brain during a nociceptive conditioned response

被引：6

作者：

Saul'skaya N.B. ^{[1
]}

Marsden Ch.A. ^{[1
]}

机构：

来源：

Neuroscience and Behavioral Physiology | 1998年 / 28卷 / 1期

基金：

俄罗斯基础研究基金会;

关键词：

Behavior; Brain; Chromatography; Extracellular space;

D O I：

10.1007/BF02461913

中图分类号：

学科分类号：

摘要：

Studies on Lister rats, using intracerebral dialysis in behaving animals combined with high-performance liquid chromatography with electrochemical detection, showed that the development and realization of an emotional conditioned response were accompanied by increases in the γ-aminobutyric acid (GABA) levels in the extracellular space of the medial part of the nucleus accumbens. Regression analysis demonstrated that measures of investigative behavior (horizontal movements, rearings, and sniffing and grooming times) during quenching of the emotional conditioned response (but not on presentation of the experimental chamber to control rats) correlated with individual changes in the extracellular GABA levels in the nucleus accumbens. Thus, this is the first report of in vivo recording of changes in GABA levels in the extracellular space of the brain during realization of normal behavior. ©1998 Plenum Publishing Corporation.

引用

页码：60 / 64

页数：4

共 14 条

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