Coexisting primary early gastric plasmacytoma and sarcoidosis with hypercalcaemia

被引：0

作者：

Shinji Morii

K. Oka

Yoshibumi Naoi

Tomoe Kotsuji

Takeshi Nihei

Reizo Nagayama

Keiji Kashimura

Sadahiko Kameta

Yasushi Yatabe

Naoyoshi Mori

机构：

[1] Department of Internal Medicine,

[2] Mito Saiseikai General Hospiral,undefined

[3] Ibaraki 311-41,undefined

[4] Japan,undefined

[5] Department of Pathology,undefined

[6] Mito Saiseikai General Hospital,undefined

[7] 3-3-10 Futubadai,undefined

[8] Mito,undefined

[9] Ibaraki 311-41,undefined

[10] Japan,undefined

[11] Department of Dermatology,undefined

[12] Mito Saiseikai General Hospital,undefined

[13] Ibaraki 311-41,undefined

[14] Japan,undefined

[15] Kameta Hospital,undefined

[16] Mito,undefined

[17] Ibaraki,undefined

[18] Japan,undefined

[19] Department of Pathology and Clinical Laboratories,undefined

[20] Aichi Cancer Centre Hospital,undefined

[21] Nagoya,undefined

[22] Aichi,undefined

[23] Japan,undefined

[24] Department of Pathology,undefined

[25] Nagoya University of School of Medicine,undefined

[26] Nagoya,undefined

[27] Aichi,undefined

[28] Japan,undefined

来源：

Virchows Archiv | 1998年 / 432卷

关键词：

Key words Primary gastric plasmacytoma; Sarcoidosis; Hypercalcaemia; Parathyroid hormone-related peptide;

D O I：

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学科分类号：

摘要：

We report on a 61-year-old woman with coexisting early stage primary gastric plasmacytoma and sarcoidosis with hypercalcaemia. Laboratory data on admission showed hypercalcaemia, with 12.8 mg/dl, parathyroid hormone-related peptide (PTHrP) 1.2 pmol/l, C-PTHrP 69.5 pmol/l, and 1,25-dihydroxyvitamin D3 46.7 pg/ml. Neoplastic plasma cells proliferated in the propria mucosa of the stomach, showed a monoclonal immunoglobulin of cytoplasmic IgA (lambda light chain) and were positive for leucocyte common antigen and epithelial membrane antigen on paraffin section prepared from a stomach biopsy specimen. Russel bodies were present, as were crystals. Abundant sarcoid granulomas were observed in many of the regional lymph nodes around the stomach and in the dermis of a skin nodule. The patient underwent subtotal gastrectomy with administration of antimyeloma chemotherapy. We suggest that the hypercalcaemia in this patient was due to PTHrP production by neoplastic plasma cells.

引用

页码：473 / 476

页数：3