Temporal Characteristics of Stress-Induced Decrease in Benzodiazepine Reception in C57Bl/6 and BALB/c Mice

被引：0
|
作者：
M. A. Yarkova
S. B. Seredenin
机构：
[1] Russian Academy of Medical Sciences,Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 157卷
关键词：
GABA; receptor; H-flunitrazepam; inbred mice; open-field test; “contact with predator” test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the duration of the drop of specific 3H-flunitrazepam binding by synaptosomal membranes from the brain of C57Bl/6 and BALB/c mice after open-field and “contact with predator” tests. It was found that reduced benzodiazepine reception in BALB/c mice after open-field test persisted for 1.5 h, but no changes of this parameter were found in C57Bl/6 mice. After contact with predator, the binding capacity of the benzodiazepine site of GABAA receptor was reduced for 8 h in BALB/c mice and for 24 h in C57Bl/6 mice.
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页码：762 / 764
页数：2
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