Synthesis and Antiviral Activity of Amino-Acid Conjugates of Glycyrrhetic Acid

被引：0
作者：
L. A. Baltina
M. V. Khudobko
L. R. Mikhailova
L. A. Baltina
V. A. Fedorova
Ya. A. Orshanskaya
V. V. Zarubaev
O. I. Kiselev
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Scientific Center
[2] Ministry of Healthcare of the Russian Federation,Research Institute of Influenza
来源：
Chemistry of Natural Compounds | 2014年 / 50卷
关键词：
triterpenoids; licorice; glycyrrhetic acid; acid chloride; amino acids; influenza A/H1N1 virus; antiviral activity;
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摘要：
Conjugates of glycyrrhetic acid (GLA) with amino acids (L-isoleucine, -leucine, -valine, and -phenylalanine) were synthesized by the acid-chloride method using methyl or tert-butyl esters of the acids. Tests in MDCK cell culture showed that the GLA conjugate with phenylalanine exhibited high antiviral activity against influenza A/H1N1/pdm09 virus (ED50 = 4.4 μg/mL, SI = 161).
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页码：473 / 477
页数：4
相关论文
共 27 条
[1]  
Graebin CS(2010)undefined J. Braz. Chem. Soc. 21 1595-undefined
[2]  
Verli H(2013)undefined Bioorg. Med. Chem. Lett. 23 2566-undefined
[3]  
Guimaraes JA(2011)undefined Eur. J. Med. Chem. 46 5356-undefined
[4]  
Kalani K(2009)undefined Eur. J. Pharmacol. 606 269-undefined
[5]  
Kushwaha V(2000)undefined Zh. Org. Khim. 36 1013-undefined
[6]  
Verna R(1986)undefined Chem. Nat. Compd. 21 605-undefined
[7]  
Murthy PK(1983)undefined J. Immunol. Methods 65 55-undefined
[8]  
Srivastava SK(undefined)undefined undefined undefined undefined-undefined
[9]  
Csuk R(undefined)undefined undefined undefined undefined-undefined
[10]  
Schwarz S(undefined)undefined undefined undefined undefined-undefined
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