Effect of β-alanine administration on carbon tetrachloride-induced acute hepatotoxicity

被引：0
作者：
S. Y. Lee
Y. C. Kim
机构：
[1] Seoul National University,College of Pharmacy
[2] Seoul National University,Research Institute of Pharmaceutical Sciences
来源：
Amino Acids | 2007年 / 33卷
关键词：
Keywords: β-Alanine – Carbon tetrachloride – Cysteine – Glutathione – Taurine;
D O I：
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学科分类号：
摘要：
Mice were supplemented with β-alanine (3%) in drinking water for one week. β-Alanine intake reduced hepatic taurine levels, but elevated cysteine levels significantly. Hepatotoxicity of CCl4 in mice fed with β-alanine was decreased as determined by changes in serum enzyme activities. Hepatic glutathione and taurine concentrations after CCl4 challenge were increased markedly by β-alanine intake. The enhanced availability of cysteine for synthesis of glutathione and/or taurine appears to account for the hepatoprotective effects of β-alanine against CCl4-induced liver injury.
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页码：543 / 546
页数：3
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