Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

被引:0
作者
Ali G. Karaji
David Reiss
Audrey Matifas
Brigitte L. Kieffer
Claire Gavériaux-Ruff
机构
[1] Université de Strasbourg,IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale
[2] Kermanshah University of Medical Sciences,Department of Immunology, School of Medicine
来源
Journal of Neuroimmune Pharmacology | 2011年 / 6卷
关键词
Opioid receptor; Mu; Delta; Kappa; Knockout; Cytokine;
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学科分类号
摘要
Here, we evaluated the influence of endogenous opioid activation on immune responses by examining consequences of all three opioid receptor gene (mu, delta and kappa) inactivation. In triple-opioid receptor knockout mice, splenocytes and thymocytes numbers, lymphocyte subsets as well as proliferation and cytokines induced by in vitro stimulation of T lymphocytes were measured. Compared with wild-type mice, similar lymphocyte distribution in thymus and spleen as well as comparable T lymphocyte proliferation were observed, while lower levels of IL-2 and IFNγ as well as higher levels of IL-4 and IL-10 were found in triple-opioid receptor knockout mice. Together, our results indicate a shift from TH1 to TH2 cytokines in triple-opioid receptor knockout animals, suggesting that global endogenous opioid tone drives T lymphocytes toward a TH1 profile under non-pathological conditions.
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页码:608 / 616
页数:8
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