The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction

被引：0
作者：
Danielle Burger
Jean-Michel Dayer
机构：
[1] University Hospital,Division of Immunology and Allergy, Clinical Immunology Unit
来源：
Arthritis Research & Therapy | / 4卷
关键词：
cytokines; inflammation; monocytes; rheumatoid arthritis; T lymphocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Contact-mediated signaling of monocytes by human stimulated T lymphocytes (TL) is a potent proinflammatory mechanism that triggers massive upregulation of the proinflammatory cytokines IL-1 and tumor necrosis factor-α. These two cytokines play an important part in chronic destructive diseases, including rheumatoid arthritis. To date this cell–cell contact appears to be a major endogenous mechanism to display such an activity in monocyte-macrophages. Since TL and monocyte-macrophages play a pivotal part in the pathogenesis of chronic inflammatory diseases, we investigated the possible ligands and counter-ligands involved in this cell–cell interaction. We also characterized an inhibitory molecule interfering in this process, apolipoprotein A-I. This review aims to summarize the state of the art and importance of contact-mediated monocyte activation by stimulated TL in cytokine production in rheumatoid arthritis and mechanisms that might control it.
引用
收藏
相关论文
共 292 条
[51]  
Smeets TJM(1998)Frequency of antibodies to the cholesterol transport protein apolipoprotein A1 in patients with SLE. Lupus 7 355-213
[52]  
Daha MR(2000)Interferon beta-1a therapy changes lipoprotein metabolism in patients with multiple sclerosis. Clin Chem Lab Med 38 209-126
[53]  
Kluin PM(1999)Atherosclerosis – an inflammatory disease. N Engl J Med 340 115-2922
[54]  
Meijers KAE(2000)Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102 2919-1822
[55]  
Brand R(1999)Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation 100 1816-325
[56]  
Meinders AE(2000)Inflammation-mediated rheumatic diseases and atherosclerosis. Ann Rheum Dis 59 321-201
[57]  
Breedveld FC(1999)High-density lipoprotein receptors, binding proteins, and ligands. J Lipid Res 40 187-661
[58]  
Smeets TJ(1999)The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endo-cytosis of high-density lipoprotein. Nat Med 5 656-9960
[59]  
Kraan MC(2001)Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. J Biol Chem 276 9955-4416
[60]  
Galjaard S(2001)Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein. Biochemistry 40 4407-2667
12345678910