Plasma metabolites and physical function in patients undergoing hemodialysis

被引：1

作者：

Moorthi, Ranjani N. ^{[1
]}

Moe, Sharon M. ^{[1
]}

O'Connell, Thomas ^{[1
]}

Dickinson, Stephanie ^{[2
]}

Kalim, Sahir ^{[3
]}

Thadhani, Ravi ^{[3
]}

Clish, Clary B. ^{[4
]}

Shafi, Tariq ^{[5
]}

Rhee, Eugene P. ^{[3
]}

Avin, Keith G. ^{[1
,6
]}

机构：

[1] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[2] Indiana Univ, Dept Sociol, Bloomington, IN USA

[3] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[4] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[5] Univ Mississippi, Med Ctr, Dept Med, Jackson, MI 39216 USA

[6] IUPUI, Sch Hlth & Human Sci, Indianapolis, IN 46202 USA

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Metabolites; Gait speed; Grip strength; Hemodialysis; ALL-CAUSE MORTALITY; HANDGRIP STRENGTH; WALKING SPEED; PERFORMANCE; ACYLCARNITINES; TAURINE;

D O I：

10.1038/s41598-024-58522-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Impaired physical function contributes to falls, fractures, and mortality among patients undergoing dialysis. Using a metabolomic approach, we identified metabolite alterations and effect size-based composite scores for constructs of impaired gait speed and grip strength. 108 participants incident to dialysis had targeted plasma metabolomics via liquid chromatography-mass spectrometry and physical function assessed (i.e., 4 m walk, handgrip strength). Physical function measures were categorized as above/ below median, with grip utilizing sex-based medians. To develop composite scores, metabolites were identified via Wilcoxon uncorrected p < 0.05 and effect size > 0.40. Receiver operating characteristic analyses tested whether scores differentiated between above/below function groups. Participants were 54% male, 77% Black and 53 +/- 14 y with dialysis vintage of 101 +/- 50 days. Median (IQR) grip strength was 35.5 (11.1) kg (males) and 20 (8.4) kg (females); median gait speed was 0.82 (0.34) m/s. Of 246 measured metabolites, composite scores were composed of 22 and 12 metabolites for grip strength and gait speed, respectively. Area under the curve for metabolite composite was 0.88 (gait) and 0.911 (grip). Composite scores of physical function performed better than clinical parameters alone in patients on dialysis. These results provide potential pathways for interventions and needed validation in an independent cohort.

引用

页数：9

共 44 条

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