PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients

被引:0
|
作者
Wei-feng Wang
Yan Xie
Zhi-hua Zhou
Zheng-hong Qin
Jun-chao Wu
Jing-kang He
机构
[1] First Affiliated Hospital of Soochow University,Department of Chest Surgery
[2] The 101st Hospital of the People's Liberation Army,Department of Pathology
[3] Laboratory of Aging and Nervous Diseases,undefined
[4] Soochow University,undefined
来源
关键词
esophageal cancer; oncogene; PIK3CA; PI3K/AKT pathway; gene mutation; methylation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1560 / 1567
页数:7
相关论文
共 50 条
  • [1] PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients
    Wang, Wei-feng
    Xie, Yan
    Zhou, Zhi-hua
    Qin, Zheng-hong
    Wu, Jun-chao
    He, Jing-kang
    ACTA PHARMACOLOGICA SINICA, 2013, 34 (12) : 1560 - 1567
  • [2] Activation of the PI3K/AKT pathway and PIK3CA mutations in Merkel cell carcinoma
    Hafner, C.
    Houben, R.
    Baeurle, A.
    Landthaler, M.
    Becker, J. C.
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2010, 8 (09): : 739 - 739
  • [3] The effect of LKB1 on the PI3K/Akt pathway activation in association with PTEN and PIK3CA in HNC
    Ekizoglu, S.
    Dogan, S.
    Ulker, D.
    Seven, D.
    Gozen, E. D.
    Karaman, E.
    Buyru, N.
    CLINICAL OTOLARYNGOLOGY, 2015, 40 (06) : 622 - 628
  • [4] PIK3CA regulates development of diabetes retinopathy through the PI3K/Akt/mTOR pathway
    Guan, Ruijuan
    Kang, Zefeng
    Li, Ling
    Yan, Xin
    Gao, Tianpeng
    PLOS ONE, 2024, 19 (01):
  • [5] Unilateral focal palmoplantar keratoderma associated with a postzygotic variant in PIK3CA and activation of the PI3K/AKT/mTOR pathway
    Gong, Zhuoqing
    Peng, Sha
    Wang, Huijun
    Jiang, Xingyuan
    Ke, Xiaoping
    Lin, Zhimiao
    EUROPEAN JOURNAL OF DERMATOLOGY, 2024, 34 (03) : 287 - 293
  • [6] Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer
    Ito, Chie
    Nishizuka, Satoshi S.
    Ishida, Kazuyuki
    Uesugi, Noriyuki
    Sugai, Tamotsu
    Tamura, Gen
    Koeda, Keisuke
    Sasaki, Akira
    JOURNAL OF SURGICAL RESEARCH, 2017, 212 : 195 - 204
  • [7] PIK3CA Mutations PREDICT RESPONSE TO PI3K/AKT/mTOR INHIBITORS
    不详
    CANCER DISCOVERY, 2012, 2 (03) : 205 - 205
  • [8] Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K/Akt/Raptor pathway
    Zhihang Chen
    Chun Wang
    Hao Dong
    Xing Wang
    Feng Gao
    Sen Zhang
    Xiaolong Zhang
    Molecular Medicine, 2020, 26
  • [9] Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K/Akt/Raptor pathway
    Chen, Zhihang
    Wang, Chun
    Dong, Hao
    Wang, Xing
    Gao, Feng
    Zhang, Sen
    Zhang, Xiaolong
    MOLECULAR MEDICINE, 2020, 26 (01)
  • [10] Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    Lee, S
    Choi, EJ
    Jin, CB
    Kim, DH
    GYNECOLOGIC ONCOLOGY, 2005, 97 (01) : 26 - 34