Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors

被引：0

作者：

Yukinari Kato

Isoji Sasagawa

Mika Kaneko

Motoki Osawa

Naoya Fujita

Takashi Tsuruo

机构：

[1] Institute of Molecular and Cellular Biosciences,Department of Experimental and Forensic Pathology

[2] The University of Tokyo,Department of Urology

[3] 1-1-1,undefined

[4] Yayoi,undefined

[5] Bunkyo-ku,undefined

[6] Yamagata University School of Medicine,undefined

[7] 2-2-2,undefined

[8] Iida-nishi,undefined

[9] Yamagata University School of Medicine,undefined

[10] 2-2-2,undefined

[11] Iida-nishi,undefined

[12] Cancer Chemotherapy Center,undefined

[13] Japanese Foundation for Cancer Research,undefined

[14] 1-37-1,undefined

[15] Kami-Ikebukuro,undefined

[16] Toshima-ku,undefined

来源：

Oncogene | 2004年 / 23卷

关键词：

Aggrus; seminoma; embryonal carcinoma; germ cell tumor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Aggrus (also known as T1α/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated with tumor-induced platelet aggregation and tumor metastasis. Here we show, by means of cancer profiling array and real-time PCR, that aggrus mRNA expression is frequently upregulated in testicular germ cell tumors when compared with the surrounding normal tissue. Immunohistochemical staining revealed that Aggrus protein expression was detected in 10 of 11 seminomas (90.9%), but its expression was not observed in embryonal carcinomas (0/4; 0%). Specific markers for seminomas have not been reported, and Aggrus is a potential diagnostic marker for seminomas and may be associated with malignancies of the testis.

引用

页码：8552 / 8556

页数：4