Genetic polymorphisms and multiple myeloma risk: a meta-analysis

被引：0
作者：
Pengcheng Zhang
Bing Liu
机构：
[1] Academy of Military Medical Sciences,Institute of environment and operational medicine
[2] Academy of Military Sciences,State Key Laboratory of Proteomics
[3] Academy of Military Medical Sciences,State Key Laboratory of Experimental Hematology
[4] Academy of Military Sciences,undefined
[5] Fifth Medical Center of Chinese PLA General Hospital,undefined
来源：
Annals of Hematology | 2020年 / 99卷
关键词：
Interleukin-6; Multidrug resistance 1; Multiple myeloma; Methylenetetrahydrofolate reductase; Tumor necrosis factor-α;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Previous researches exploring associations between multiple myeloma (MM) and genetic polymorphisms showed controversial results. In this investigation, we aimed to make a meta-analysis to assess the association between MM risk and genetic polymorphisms. We searched for articles on genetic polymorphism and MM risk in Web of Science and PubMed databases from 1951 to August 2019. We computed the odds ratio (OR) and 95% confidence intervals (CI) extracted from included articles. The meta-analysis showed no significant associations between MM risks and tumor necrosis factor (TNF)-α (rs1800629/rs361525/rs1799724), interleukin (IL)-6 (rs1800795), multidrug resistance 1 (MDR1) (rs1045642), Methylenetetrahydrofolate reductase (MTHFR) (rs1801131/rs1801133) polymorphisms. In summary, the study shows that the TNF-α (rs1800629/rs361525/rs1799724), IL-6 (rs1800795), MDR1 (rs1045642), and MTHFR (rs1801131/rs1801133) polymorphisms may not be associated with MM susceptibility. Thus, we do not need more expensive and useless studies to explore the associations between MM risks and these genetic polymorphisms.
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页码：1017 / 1024
页数：7
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