Pyrimidinophanes are macrocycles consisting of pyrimidine moieties bridged to each other with alkyl spacers. Most of the known pyrimidinophanes originate from pyrimidinic nucleobase uracil and its 5(6)-substituted derivatives. Diverse macrocyclic compounds with pyrimidine moieties have appeared during the last two decades, and in this review the synthesis and properties of the pyrimidinophanes studied have been described.