Neutrophil elastase in bronchiectasis

被引：0
作者：
Andrea Gramegna
Francesco Amati
Leonardo Terranova
Giovanni Sotgiu
Paolo Tarsia
Daniela Miglietta
Maria Adelaide Calderazzo
Stefano Aliberti
Francesco Blasi
机构：
[1] University of Milan,Department of Pathophysiology and Transplantation
[2] Internal Medicine Department,Department of Clinical Sciences and Community Health University of Milano, Paediatric Highly Intensive Care Unit
[3] Respiratory Unit and Cystic Fibrosis Adult Center,Department of Biomedical Sciences, Clinical Epidemiology and Medical Statistics Unit
[4] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined
[5] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined
[6] University of Sassari,undefined
[7] Corporate Pre-Clinical R&D,undefined
[8] Chiesi Farmaceutici SpA,undefined
[9] Global Clinical Development,undefined
[10] Chiesi Farmaceutici SpA,undefined
来源：
Respiratory Research | / 18卷
关键词：
Bronchiectasis; Neutrophil elastase; Protease; Neutrophil elastase inhibitors; Desmosine;
D O I：
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中图分类号：
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摘要：
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed.
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[1]  
Mantovani A(2011)Neutrophils in the activation and regulation of innate and adaptive immunity Nat Rev Immunol 11 519-531
[2]  
Cassatella MA(2016)Neutrophil heterogeneity: implications for homeostasis and pathogenesis Blood 127 2173-2181
[3]  
Costantini C(1980)Release of inflammatory mediators from stimulated neutrophils N Engl J Med 303 27-34
[4]  
Jaillon S(1990)Neutrophil elastase cleaves C3bi on opsonised pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch J Clin Invest 86 300-308
[5]  
Silvestre-Roig C(1984)Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect Thorax 39 663-667
[6]  
Hidalgo A(1991)Effects of human neutrophil elastase and Pseudomonas Aeruginosa proteinases on human respiratory epithelium Am J Respir Cell Mol Biol 4 26-32
[7]  
Soehnlein O(1984)Phagolysosomal pH of human neutrophils Blood 63 88-95
[8]  
Weissmann G(1995)Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases J Cell Biol 131 775-789
[9]  
Smolen JE(2004)Neutrophil extracellular traps kill bacteria Science 303 1532-1535
[10]  
Korchak HM(2013)Neutrophil elastase-mediated lung disease COPD. 10 60-63
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