Revised WHO histological classification of urothelial bladder tumors and flat urothelial lesions [Neuerungen in der histologischen WHO-klassifikation urothelialer harnblasentumoren und abnormer flacher urothellasionen]

被引：0

作者：

Helpap B. ^{[1
]}

Köllermann J. ^{[1
]}

机构：

[1] Institut für Pathologie, 78207 Singen

来源：

Der Pathologe | 2000年 / 21卷 / 3期

关键词：

Flat and papillary urothelial lesions/tumors; Histology; Immunohistochemistry; Urothelial bladder tumors; WHO classification;

D O I：

10.1007/s002920050390

中图分类号：

学科分类号：

摘要：

Recently the World Health Organization published a new classification of urinary bladder tumors which is intended to take into account better the biology of the various lesions and to better distinguish between clearly benign and malignant lesions. We examine the possible diagnostic and clinical impact of the new classification, including recent immunohistochemical findings. Papillary urothelial lesions include papillomas, papillary neoplasms of low malignant potential, and papillary carcinomas. Flat urothelial lesions include hyperplasia, reactive atypia/atypia of unknown significance, dysplasia, and carcinoma in situ. Invasive patterns of papillary carcinomas are discussed, with special emphasis on lamina muscularis mucosae substaging. The most important feature of the new classification is its differentiation of two types of low-grade, noninvasive papillary urothelial lesions: papillary neoplasm of low malignant potential vs. papillary carcinoma. Long-term follow-up studies are needed to determine the clinical significance of this differentiation.

引用

页码：211 / 217

页数：6

共 26 条

[1]

Angulo J.C., Lopez J.I., Re: The importance of the depth of invasion in stage T1 bladder carcinoma: A prospective cohort study, J Urol, 158, pp. 1922-1923, (1997)

[2]

Angulo J.C., Lopez J.I., Grignon D.J., Sanchez-Chapado M., Muscularis mucosa differentiates two populations with different prognosis in stage T1 bladder cancer, Urology, 45, pp. 47-53, (1995)

[3]

Cheng L., Cheville J.C., Neumann R.M., Bostwick D.G., Natural history of urothelial dysplasia of the bladder, Am J Surg Pathol, 23, pp. 332-447, (1999)

[4]

Cheng L., Cheville J.C., Neumann R.M., Bostwick D.G., Flat intraepithelial lesions of the urinary bladder, Cancer, 88, pp. 625-631, (2000)

[5]

Cheng L., Darson M., Cheville J.C., Neumann R.M., Zincke H., Nehra A., Bostwick D.G., Urothelial papilloma of the bladder. Clinical and biologic implications, Cancer, 86, pp. 2098-2101, (1999)

[6]

Cheng L., Neumann R.M., Bostwick D.G., Papillary urothelial neoplasms of low malignant potential. Clinical and biologic implications, Cancer, 86, pp. 2102-2108, (1999)

[7]

Cheng L., Weaver A.L., Neumann R.M., Scherer B.G., Bostwick D.G., Substaging of T1 bladder carcinoma based on the depth of invasion as measured by micrometer: A new proposal, Cancer, 86, pp. 1035-1043, (1999)

[8]

Epstein J.I., Amin M.B., Reuter V.R., Mostofi F.K., The World Health Organisation/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder, Am J Surg Pathol, 22, pp. 1435-1448, (1998)

[9]

Harnden P., Eardlex I., Joyce A.D., Southgate J., Cytokeratin 20 as an objective marker of urothelial dysplasia, Br J Urol, 78, pp. 870-875, (1996)

[10]

Harnden P., Southgate J., Revised classification of urothelial neoplasms, Am J Surg Pathol, 24, pp. 160-161, (2000)

← 1 2 3 →