Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

被引：0
|
作者：
Marcus Vinícius Mariano Nascimento
Pablinny Moreira Galdino
Iziara Ferreira Florentino
Bruno Leite Sampaio
Frederico Argollo Vanderlinde
José Realino de Paula
Elson Alves Costa
机构：
[1] Universidade Federal de Goiás,Laboratorio de Farmacologia de Produtos Naturais, Sala 216, Instituto de Ciências Biológicas
[2] Universidade Federal Rural do Rio de Janeiro,2
[3] Universidade Federal de Goiás,Departamento de Ciências Fisiológicas
来源：
Journal of Natural Medicines | 2011年 / 65卷
关键词：
Medicinal plants; Analgesic activity; Bioactivity-guided fractionation; Neurogenic pain; Formalin test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
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页码：448 / 454
页数：6
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