The interplay between immunosenescence and age-related diseases

被引：0
作者：
Florencia Barbé-Tuana
Giselle Funchal
Carine Raquel Richter Schmitz
Rafael Moura Maurmann
Moisés E. Bauer
机构：
[1] Pontifical Catholic University of Rio Grande do Sul (PUCRS),Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences
[2] Federal University of Rio Grande do Sul (UFRGS),Graduate Program in Cell Biology: Biochemistry
[3] PUCRS,Graduate Program in Biomedical Gerontology
来源：
Seminars in Immunopathology | 2020年 / 42卷
关键词：
Aging; Inflammaging; Cytokines; T cells; Cell senescence; Immunosenescence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28−), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.
引用
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页码：545 / 557
页数：12
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