MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer

被引：0
作者：
Nicole MA White
George M Yousef
机构：
[1] and the Keenan Research Centre in the Li Ka Shing Knowledge Institute,Department of Laboratory Medicine
[2] St Michael's Hospital,Department of Laboratory Medicine and Pathobiology
[3] University of Toronto,undefined
来源：
BMC Medicine | / 8卷
关键词：
Renal Cell Carcinoma; miRNA Expression; miRNA Target; Kidney Cancer; Renal Cell Carcinoma Patient;
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摘要：
Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. The role of the von-Hippel-Lindeau (VHL) tumour suppressor gene is well established in RCC with a loss of VHL protein leading to accumulated hypoxia-induced factor (HIF) and the subsequent transcriptional activation of multiple downstream targets. Recently, microRNAs (miRNAs) have been shown to be differentially expressed in RCC and their role in RCC pathogenesis is emerging. This month, in BMC Medicine, Gleadle and colleagues show that certain miRNAs are regulated by VHL in either a hypoxia-inducible factor (HIF)-dependent or HIF-independent manner in RCC. They also show that miRNA expression correlates with the survival of RCC patients.
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