Study of the interaction between cyclodextrins and liposome membranes: effect on the permeability of liposomes

被引：0
|
作者：
G. Piel
M. Piette
V. Barillaro
D. Castagne
B. Evrard
L. Delattre
机构：
[1] University of Liège,Laboratory of Pharmaceutical Technology, Department of Pharmacy
[2] Chu,Laboratory of Pharmaceutical Technology, Department of Pharmacy
[3] Tour 4,undefined
[4] Bat B36,undefined
[5] University of Liège,undefined
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2007年 / 57卷
关键词：
Liposome; Cyclodextrin; Cholesterol; Calcein; Membrane permeability;
D O I：
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中图分类号：
学科分类号：
摘要：
We wanted to compare and understand the effect of the most currently used cyclodextrins on a model membrane. We studied the influence of most currently used cyclodextrins on the release of a fluorescent marker encapsulated in the inner cavity of SUV liposomes. It was shown that the observed effect on calcein release can be directly related to the affinity of cyclodextrins for both lipid components of liposomes, cholesterol and phosphatidylcholine. From this relationship, we were able to determine, for each cyclodextrin, a theoretical concentration giving rise to 50% or 100% calcein release. This theoretical concentration was confirmed experimentally.
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页码：309 / 311
页数：2
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