Chemoprotective effects of Allium cepa and Allium sativum on lead acetate–mediated oxidative stress and dyslipidemia in Wistar rats

被引：0

作者：

Eze C.W. ^{[1
]}

Nweze E.I. ^{[2
]}

Nsude C.A. ^{[3
]}

机构：

[1] Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Enugu Sate University of Science and Technology (ESUT), Enugu

[2] Department of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu

[3] Department of Applied Biochemistry, Enugu State University of Science and Technology, Enugu

来源：

Comparative Clinical Pathology | 2021年 / 30卷 / 1期

关键词：

Allium cepa; Allium sativum; Chemoprotection; Dyslipidemia; Lead acetate; Oxidative stress; Rats;

D O I：

10.1007/s00580-021-03196-2

中图分类号：

学科分类号：

摘要：

Chemoprotective effects of Allium cepa and Allium sativum on lead acetate–mediated oxidation stress and dyslipidemia were investigated in Wistar rats. Seventy-five acclimatized rats were fed standard feed and distilled water ad libitum. The Wistar rats weighing 160 to 170 g were randomly divided into five groups of fifteen rats each. Group I served as control. Group II received oral administration of 75 mg/kg of lead acetate. Group III animals received oral administration of 75 mg/kg of lead acetate and 1 ml in 200 g Allium cepa juice. Group IV rats received oral administration of 1 ml/ 200 g of Allium cepa juice. Group V rats received 75 mg/kg of lead acetate and vitamin E (α-tocopherol) as standard antioxidant via oral gavage based on the weight of each rat at a dose of 10 mg/100 g BW of rat. The feeding procedure was repeated with Allium sativum juice. The feeding process lasted for 4 weeks. Animals were sacrificed and blood collected by cardiac puncture and labeled appropriately. Exposure to lead acetate resulted to a significant (p = 0.034) elevation in total cholesterol, low-density lipoprotein, triacylglycerol, very low-density lipoprotein, and malondialdehyde (MDA) but also caused a significant reduction in high-density lipoprotein, glutathione, superoxide dismutase, and catalase activities. Allium cepa/Allium sativum treatment of the lead acetate–exposed rats exhibited a significant (p = 0.025) increase in high-density lipoprotein, superoxide dismutase, catalase, and glutathione levels and showed a significant (p = 0.042) decrease in total cholesterol and malondialdehyde (MDA) concentrations. There was no significant (p = 0.006) difference when the results of the effects of Allium cepa and Allium sativum on lead acetate–exposed rats were compared to the effects of vitamin E (standard antioxidant). In conclusion, Allium cepa and Allium sativum mitigated oxidative stress and dyslipidemia in lead acetate–exposed Wistar rats, and thus, suggests protective effects on cardiovascular diseases. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature.

引用

页码：89 / 95

页数：6

共 25 条

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