DOCK8 Deficiency Presenting as an IPEX-Like Disorder

被引:0
作者
Fayhan J. Alroqi
Louis-Marie Charbonnier
Sevgi Keles
Fatima Ghandour
Pierre Mouawad
Rami Sabouneh
Reem Mohammed
Abduarahman Almutairi
Janet Chou
Michel J. Massaad
Raif S. Geha
Zeina Baz
Talal A. Chatila
机构
[1] Harvard Medical School,Division of Immunology, Boston Children’s Hospital and Department of Pediatrics
[2] King Saud bin Abdulaziz University for Health Sciences,Department of Pediatrics, King Abdulaziz Medical City
[3] Necmettin Erbakan University,Division of Pediatric Allergy and Immunology
[4] St George Hospital University Medical Center,Department of Pathology
[5] St George Hospital University Medical Center,Department of Pediatrics
来源
Journal of Clinical Immunology | 2017年 / 37卷
关键词
Combined Immunodeficiency; DOCK8; FOXP3; immune dysregulation; IPEX; IPEX-like; regulatory T cells; T;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:811 / 819
页数:8
相关论文
共 227 条
[1]  
Cote JF(2007)What? Dock180 and related proteins help Rac to polarize cells in new ways Trends Cell Biol 17 383-393
[2]  
Vuori KGEF(2010)DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction Dis Markers 29 151-156
[3]  
McGhee SA(2012)DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses Blood 119 4451-4461
[4]  
Chatila TA(2013)Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency J Allergy Clin Immunol 131 840-848
[5]  
Harada Y(2013)Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity J Immunol 190 3661-3669
[6]  
Tanaka Y(2016)A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton J Clin Invest 126 3837-3851
[7]  
Terasawa M(2014)DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity J Exp Med 211 2549-2566
[8]  
Pieczyk M(2016)Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation J Allergy Clin Immunol 138 1384-1394
[9]  
Habiro K(2017)Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells J Allergy Clin Immunol 139 933-949
[10]  
Katakai T(2012)DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation Nat Immunol 13 612-620